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Cathepsins

Cathepsins, the lysosomal proteinases, are distributed in normal tissues and expressed in a variety of physiological and pathophysiological processes such as bone resorption, muscular dystrophy, arthritis and tumor invasion and metastasis.
They are synthesized as proenzymes which are processed to the active form by removal of proregion.
Mature cathepsins are localized in the lysosomes where they function in protein turnover but have also been shown to be capable of degrading ECM proteins. Higher levels of several cathepsins have been associated with thepathological destruction of the ECM leading to tumor metastasis, osteoporosis and rheumatoid arthritis.

Monoclonal Antibodies : Cathepsins

No.	Product	Antigen	Isotype	Clone	Appli-cation	Spe-cies	Epitope
F-92	Anti-Human Cathepsin K	Peptide** (R182-195)	Mouse MAb IgG1/kappa	182- 12G5	WB	H	-
F-103	Anti-Human Cathepsin F	Recombinant human Cathepsin F	Mouse MAb IgG1/kappa	233-3D4	WB	H	-
F-104	Anti-Human Cathepsin F	Recombinant human Cathepsin F	Mouse MAb IgG1/kappa	233-13D2	WB	H	-
F-105	Anti-Human Cathepsin L2	Recombinant human Cathepsin L2	Mouse MAb IgG2a/kappa	236-2D8	WB	H	-
F-106	Anti-Human Cathepsin L2	Recombinant human Cathepsin L2	Mouse MAb IgG2b/kappa	236-8C9	WB	H	-
F-107	Anti-Human Cathepsin Z	Recombinant human Cathepsin Z	Mouse MAb IgG1/kappa	237-2D10	WB	H	-
F-108	Anti-Human Cathepsin Z	Recombinant human Cathepsin Z	Mouse MAb IgG1/kappa	237-11B4	WB	H	-

***:numbered from propeptide. R:residue

EIA:Enzyme Immunoassay, WB:Western Blot, IP:Immunoprecipitation
Immunohistochemistry (FS:Frozen Section, PS:Paraffin Section)
Cross-reaction (H:Human, B:Bovine, Rb:Rabbit, r:rat, M:Mouse, G:Guinea pig, S:Sheep, P:Pig )